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1.Screening
1.1.Management for Progress
1.2.Inclusion Criteria
1.3.Exclusion Criteria
2.Baseline
2.1.Management of the progress
2.2.General information
2.3.Physical examination
2.4.Blood Routine Tests
2.5.Urine and Stool Routine Tests
2.6.Blood Electrolytes Tests
2.7.Coagulation Function Tests
2.8.Serum Liver Function Tests
2.9.HBV Markers Test
2.10.Renel Function Test
2.11.Heat Function Examination
2.12.Blood Cell Morphology
2.13.Image Examinations
2.14.Nervous System Examination
2.15.Lung Function Examination
2.16.Blood Gas Analysis
2.17.Physical Ability Examination
2.18.Health Relative Quality of Life
3.In the process of the treatment
3.1.Treatment Record
4.At the end of the treatment
4.1.Management for Progress
4.2.Physical examination
4.3.Blood Routine Tests
4.4.Urine and Stool Routine Tests
4.5.Serum Electrolytes Tests
4.6.Liver Function Tests
4.7.HBV Markers Test
4.8.Renel Function Test
4.9.Heat Function Examination
4.10.Image Examinations
4.11.Blood Cell Morphology
4.12.Nervous System Examination
4.13.Lung Function Examination
4.14.Blood Gas Analysis
4.15.Physical Sbility Examination
4.16.Health Relative Quality of Life
5.Follow-up 1
1.Blood routine test
6.Follow-up 2
7.Follow-up 3
8.Management system of participants
9.Speciman management system
10.Data management system
11.ADR/ADE management system
12.Madicine management system
13.Instruments management system
14.SOPs
14.1.Treatment SOP
14.2.Nursing SOP
14.3.Specimen collection SOP
15.Research team
15.1.Institutions
15.2.Researchers
16.Design, Methods
16.1.Calculation of sample size
17.baseline selection
17.1.1 week after insertion of implant-surpported restoration

changes to soft tissue thickness of 3mm below the gingival margin

0.22 mm

changes to soft tissue thickness of 1mm below the gingival margin

0.17 mm

changes to gingival margin

0.20 mm

changes to soft tissue thickness of 5mm below the gingival margin

0.13 mm

17.2.2 weeks after insertion of implant-surpported restoration

papilla height at mesial site

2.4 mm

changes to soft tissue thickness of 3mm below the gingival margin

0.15 mm

changes to soft tissue thickness of 1mm below the gingival margin

0.11 mm

keratinized tissue width

1.60 mm

changes to gingival margin

0.06 mm

papilla height at distal site

2.4 mm

changes to soft tissue thickness of 5mm below the gingival margin

0.08 mm

17.3.3 weeks after insertion of implant-surpported restoration

changes to soft tissue thickness of 3mm below the gingival margin

0.11 mm

changes to soft tissue thickness of 1mm below the gingival margin

0.09 mm

changes to gingival margin

-0.03 mm

changes to soft tissue thickness of 5mm below the gingival margin

0.12 mm

18.follow-up
18.1.1 month after baseline

changes to soft tissue thickness of 1mm below the gingival margin

-0.55 mm

bleeding on probing

25 %

papilla height at distal site

2.4 mm

keratinized tissue width

1.52 mm

papilla height at mesial site

3.1 mm

changes to gingival margin

-0.40 mm

changes to soft tissue thickness of 5mm below the gingival margin

-0.34 mm

changes to soft tissue thickness of 3mm below the gingival margin

-0.48 mm

gingival index

1.00

18.2.3 months after baseline

papilla height at mesial site

2.2 mm

changes to soft tissue thickness of 3mm below the gingival margin

-0.73 mm

changes to soft tissue thickness of 5mm below the gingival margin

-0.35 mm

changes to soft tissue thickness of 1mm below the gingival margin

-0.73 mm

gingival index

1.25

changes to gingival margin

-0.60 mm

bleeding on probing

25 %

papilla height at distal site

2.3 mm

keratinized tissue width

1.41 mm

18.3.6 months after baseline

changes to soft tissue thickness of 5mm below the gingival margin

-0.39 mm

papilla height at distal site

2.9 mm

changes to soft tissue thickness of 3mm below the gingival margin

-0.35 mm

gingival index

1.00

papilla height at mesial site

3.1 mm

changes to soft tissue thickness of 1mm below the gingival margin

-0.87 mm

bleeding on probing

0 %

changes to gingival margin

-0.25 mm

keratinized tissue width

1.41 mm

18.4.12 months after baseline

papilla height at mesial site

2.6 mm

changes to gingival margin

-0.36 mm

keratinized tissue width

1.34 mm

changes to soft tissue thickness of 5mm below the gingival margin

-0.31 mm

changes to soft tissue thickness of 3mm below the gingival margin

-0.89 mm

gingival index

1.00

papilla height at distal site

2.9 mm

changes to soft tissue thickness of 1mm below the gingival margin

-0.93 mm

bleeding on probing

0 %